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VX-702

CAT: 0804-HY-10401-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10401-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β[1].
CAS Number
745833-23-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; p38 MAPK
Type
Reference compound
Related Pathways
Autophagy; MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/VX-702.html
Purity
99.69
Solubility
DMSO : ≥ 42 mg/mL
Smiles
O=C(N)C1=CC=C(N=C1C2=CC=C(C=C2F)F)N(C3=C(C=CC=C3F)F)C(N)=O
Molecular Formula
C19H12F4N4O2
Molecular Weight
404.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Kuliopulos A, et al. Effect of selective inhibition of the p38 MAP kinase pathway on platelet aggregation. Thromb Haemost, 2004, 92 (6), 1387-1393.|[2]Braddock M, IDDB Meeting Report, 2005, March 14-15.|[3]Gill A, IDDB Meeing Report, 2002, March 06-08.|[4]Naka K, et al. Dipeptide species regulate p38MAPK-Smad3 signalling to maintain chronic myelogenous leukaemia stem cells. Nat Commun. 2015 Aug 20;6:8039.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Chemical Information

Vx-702

6-(N-carbamoyl-2,6-difluoroanilino)-2-(2,4-difluorophenyl)-3-pyridinecarboxamide is a phenylpyridine.

CAS Number745833-23-2
PubChem CID10341154
IUPAC Name6-(N-carbamoyl-2,6-difluoroanilino)-2-(2,4-difluorophenyl)pyridine-3-carboxamide
Molecular FormulaC19H12F4N4O2
Molecular Weight404.3
XLogP2.5
Topological Polar Surface Area102
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count29
Formal Charge0
Complexity603
SMILES
C1=CC(=C(C(=C1)F)N(C2=NC(=C(C=C2)C(=O)N)C3=C(C=C(C=C3)F)F)C(=O)N)F
InChI
InChI=1S/C19H12F4N4O2/c20-9-4-5-10(14(23)8-9)16-11(18(24)28)6-7-15(26-16)27(19(25)29)17-12(21)2-1-3-13(17)22/h1-8H,(H2,24,28)(H2,25,29)
InChIKey
FYSRKRZDBHOFAY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Vx-702
CAS: 745833-23-2
CID: 10341154
Formula: C19H12F4N4O2
MW: 404.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight404.3
XLogP32.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass404.08963829
Monoisotopic Mass404.08963829
Topological Polar Surface Area102 Ų
Heavy Atom Count29
Formal Charge0
Complexity603
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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sc-361400VX 702

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