VX-759

CAT: 0804-HY-119161Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-119161Size:1 Each

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Description

VX-759 (VCH-759) is an orally active HCV NS5B RNA-dependent RNA polymerase inhibitor. VX-759 is promising for research of chronic hepatitis C[1].

CAS Number

478025-29-5

Product Name Alternative

VCH-759

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

HCV; HCV Protease

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

O=C([C@@H]1CC[C@H](CC1)C)N(C2=C(SC(C3=CC=CC=C3)=C2)C(O)=O)C(C)C

Molecular Formula

C22H27NO3S

Molecular Weight

385.52

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Cooper C, et al. Evaluation of VCH-759 monotherapy in hepatitis C infection. J Hepatol. 2009 Jul;51 (1) :39-46. doi: 10.1016/j.jhep.2009.03.015. Epub 2009 Apr 23.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

3-{isopropyl[(Trans-4-Methylcyclohexyl)carbonyl]amino}-5-Phenylthiophene-2-Carboxylic Acid

CAS Number	478025-29-5
PubChem CID	503536
IUPAC Name	3-[(4-methylcyclohexanecarbonyl)-propan-2-ylamino]-5-phenylthiophene-2-carboxylic acid
Molecular Formula	C22H27NO3S
Molecular Weight	385.5
XLogP	5.6
Topological Polar Surface Area	85.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Heavy Atom Count	27
Formal Charge	0
Complexity	524

SMILES

CC1CCC(CC1)C(=O)N(C2=C(SC(=C2)C3=CC=CC=C3)C(=O)O)C(C)C

InChI

InChI=1S/C22H27NO3S/c1-14(2)23(21(24)17-11-9-15(3)10-12-17)18-13-19(27-20(18)22(25)26)16-7-5-4-6-8-16/h4-8,13-15,17H,9-12H2,1-3H3,(H,25,26)

InChIKey

RZXQBIKGWSLVEK-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 478025-29-5

CID: 503536

Formula: C22H27NO3S

MW: 385.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	385.5
XLogP3	5.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	385.17116490
Monoisotopic Mass	385.17116490
Topological Polar Surface Area	85.9 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	524
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-W953653	CRBN ligand-759
HY-118917	VX-148
HY-10401-01	VX-702
HY-14178-01	VX-11e
HY-16521	VX-166
HY-19939S-01	VX-984
HY-139346-01	VX-150
HY-10401R-01	VX-702 (Standard)
HY-19939S2	(R) -VX-984
HY-14178A-01	(R) -VX-11e

Alternative Products

Catalog	Name
GTR19196161-01	VX 759
BQB91313-01	VCH-759
MBS5777484-01	L-759,656
532085	L-759,633
A15479-25	VCH-759 25mg
A15479-10	VCH-759 10mg
GTR19276419-01	CRBN ligand-759
A15479-5	VCH-759 5mg
FM28353	VX 680
TRC-V900600-50MG	VX-765

VX-759

Chemical Information

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