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ABT-702 (hydrochloride)

CAT: 0804-HY-112482A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112482A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ABT-702 (hydrochloride) is a potent, orally active, and selective adenosine kinase (AK) inhibitor with an IC50 of 1.7 nM. ABT-702 (hydrochloride) shows >1300-fold selectivity for AK over other biological targets, including cyclooxygenases-1 and -2. ABT-702 (hydrochloride) attenuates inflammation in diabetic retinopathy by increasing free adenosine levels. ABT-702 (hydrochloride) shows analgesic and anti-inflammatory effects in vivo. ABT-702 (hydrochloride) can be used for diabetic retinopathy research[1][2][3].
CAS Number
2624336-92-9
Product Name Alternative
Adenosine Kinase Inhibitor (hydrochloride)
UNSPSC
12352005
Target
Adenosine Kinase; Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/abt-702-hydrochloride.html
Purity
98.29
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
NC1=C(C(C2=CC=CC(Br)=C2)=CC(C3=CC=C(N4CCOCC4)N=C3)=N5)C5=NC=N1.Cl
Molecular Formula
C22H20BrClN6O
Molecular Weight
499.79
References & Citations
[1]Jarvis MF, et al. ABT-702 (4-amino-5- (3-bromophenyl) -7- (6-morpholinopyridin-3-yl) pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects in the mouse. J Pharmacol Exp Ther. 2000 Dec;295 (3) :1156-64.|[2]Parkinson FE, et al. The Effect of Endogenous Adenosine on Neuronal Activity in Rats: An FDG PET Study. J Neuroimaging. 2016 Jul;26 (4) :403-5.|[3]Elsherbiny NM, et al. ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy. Life Sci. 2013 Jul 30;93 (2-3) :78-88.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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