VX-150

• Description:

  VX-150 is an orally active, highly selective NaV1.8 inhibitor. VX-150 has the potential for various pain indications research[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319

• Target:

  Sodium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/vx-150.html

• Purity:

  98.36

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C1C=C(NC(C2=CC=C(C(F)(F)F)C=C2OC3=CC=C(C=C3C)F)=O)C=CN1COP(O)(O)=O

• Molecular Formula:

  C21H17F4N2O7P

• Molecular Weight:

  516.34

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]Hemme J Hijma, et al. A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective NaV1.8 Inhibitor, in Healthy Male Adults. Pain Med. 2021 Aug 6;22 (8) :1814-1826.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  Nav1.8

• CAS Number:

  [1793080-72-4]