VX-150

• Description :

  VX-150 is an orally active, highly selective NaV1.8 inhibitor. VX-150 has the potential for various pain indications research[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  Sodium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/vx-150.html

• Purity :

  98.36

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C1C=C(NC(C2=CC=C(C(F)(F)F)C=C2OC3=CC=C(C=C3C)F)=O)C=CN1COP(O)(O)=O

• Molecular Formula :

  C21H17F4N2O7P

• Molecular Weight :

  516.34

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Hemme J Hijma, et al. A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective NaV1.8 Inhibitor, in Healthy Male Adults. Pain Med. 2021 Aug 6;22 (8) :1814-1826.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  Nav1.8

• CAS Number :

  [1793080-72-4]