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YS-49

CAT: 0804-HY-15477-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15477-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II) -stimulated proliferation of VSMCs via induction of heme oxygenase (HO) -1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors[1][2][3].
CAS Number
132836-42-1
UNSPSC
12352005
Hazard Statement
H302
Target
Adrenergic Receptor; Akt; Angiotensin Receptor; PI3K
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/ys-49.html
Purity
99.98
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC1=CC2=C(C(CC3=C4C=CC=CC4=CC=C3)NCC2)C=C1O.[H]Br
Molecular Formula
C20H20BrNO2
Molecular Weight
386.28
Precautions
H302
References & Citations
[1]Sun JJ, Kim HJ, Seo HG, et al. YS49,1- (alpha-naphtylmethyl) -6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1. Life Sci. 2008;82 (11-12) :600-7.|[2]Kang YJ, et al. Prevention of the expression of inducible nitric oxide synthase by a novel positive inotropic agent, YS 49, in rat vascular smooth muscle and RAW 264.7 macrophages. Br J Pharmacol. 1999 Sep;128 (2) :357-64.|[3]Hsu YH, et al. RhoA-mediated inhibition of vascular endothelial cell mobility: positive feedback through reduced cytosolic p21 and p27. J Cell Physiol. 2014 Oct;229 (10) :1455-65.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

YS-49

structure given in first source

CAS Number132836-42-1
PubChem CID10249534
IUPAC Name1-(naphthalen-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol;hydrobromide
Molecular FormulaC20H20BrNO2
Molecular Weight386.3
Topological Polar Surface Area52.5
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count24
Formal Charge0
Complexity401
SMILES
C1CNC(C2=CC(=C(C=C21)O)O)CC3=CC=CC4=CC=CC=C43.Br
InChI
InChI=1S/C20H19NO2.BrH/c22-19-11-15-8-9-21-18(17(15)12-20(19)23)10-14-6-3-5-13-4-1-2-7-16(13)14;/h1-7,11-12,18,21-23H,8-10H2;1H
InChIKey
JXFRKNGQHAAJKY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of YS-49
CAS: 132836-42-1
CID: 10249534
Formula: C20H20BrNO2
MW: 386.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight386.3
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass385.06774
Monoisotopic Mass385.06774
Topological Polar Surface Area52.5 Ų
Heavy Atom Count24
Formal Charge0
Complexity401
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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