YS-49 monohydrate

• Target:

  Akt|||RAAS|||Others|||PI3K|||Adrenergic Receptor

• Related Pathways:

  GPCR/G Protein|||Cytoskeletal Signaling|||Endocrinology/Hormones|||Neuroscience|||PI3K/Akt/mTOR signaling|||Others

• Bioactivity:

  YS-49 (monohydrate) is an isoquinoline compound alkaloid that functions as a PI3K/Akt activator, specifically targeting a downstream effect of RhoA, to mitigate the activation of RhoA/PTEN in 3-methylcholanthrene-treated cells. It also prevents the angiotensin II (Ang II) -induced proliferation of vascular smooth muscle cells (VSMCs) by promoting the expression of heme oxygenase (HO) -1. Additionally, YS-49 exerts a significant positive inotropic effect by stimulating cardiac ?-adrenoceptors, showcasing its multifaceted pharmacological activities [1] [2] [3].

• Molecular Formula:

  C20H22BrNO3

• Molecular Weight:

  404.3

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C