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YS-49 monohydrate

CAT: 0931-T75238-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T75238-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Akt, RAAS, Others, PI3K, Adrenergic Receptor
Related Pathways
GPCR/G Protein, Cytoskeletal Signaling, Endocrinology/Hormones, Neuroscience, PI3K/Akt/mTOR signaling, Others
Bioactivity
YS-49 (monohydrate) is an isoquinoline compound alkaloid that functions as a PI3K/Akt activator, specifically targeting a downstream effect of RhoA, to mitigate the activation of RhoA/PTEN in 3-methylcholanthrene-treated cells. It also prevents the angiotensin II (Ang II) -induced proliferation of vascular smooth muscle cells (VSMCs) by promoting the expression of heme oxygenase (HO) -1. Additionally, YS-49 exerts a significant positive inotropic effect by stimulating cardiac β-adrenoceptors, showcasing its multifaceted pharmacological activities [1] [2] [3].
Molecular Formula
C20H22BrNO3
Molecular Weight
404.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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