YS-67

• UNSPSC Description:

  YS-67 is a potent inhibitor of EGFR with an IC 50 of 5.2 nM. YS-67 significantly inhibits p-EGFR and p-AKT. YS-67 inhibits the proliferation of A549, PC-9, and A431cells with IC 50s of 4.1, 0.5, and 2.1 μM, respectively[1].

• Target Antigen:

  EGFR

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ys-67.html

• Solubility:

  DMSO : 20 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  COC1=C(OCCCN2CCOCC2)C=C3C(C(C4=CC=CC=C4N5CC)=C5C6=CC=CC=C6)=NC=NC3=C1

• Molecular Weight:

  522.64

• References & Citations:

  [1]He P, et al. Design, synthesis and biological evaluation of structurally new 4-indolyl quinazoline derivatives as highly potent, selective and orally bioavailable EGFR inhibitors. Bioorg Chem. 2024 Jan;142:106970.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2761327-15-3