Products for Research Use Only
RegisterLogin

HIF-1α-IN-3

CAT: 0804-HY-147813Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-147813Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
HIF-1α-IN-3 (Compound (S) -3f) is a hypoxia-selective HIF-1α inhibitor. HIF-1α-IN-3 shows strong antiestrogenic potency[1].
CAS Number
2170715-64-5
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hif-1α-in-3.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C(C2=CC=CC=C2)[N+]([O-])=C3C=CC(N4C[C@@H](N)CC4)=CC3=[N+]1[O-]
Molecular Formula
C19H17N5O2
Molecular Weight
347.37
References & Citations
[1]Buravchenko GI, et al. Discovery of derivatives of 6 (7) -amino-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides: novel, hypoxia-selective HIF-1α inhibitors with strong antiestrogenic potency. Bioorg Chem. 2020 Nov;104:104324.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Hif-1|A-IN-3
CAS Number2170715-64-5
PubChem CID142770680
IUPAC Name7-[(3S)-3-aminopyrrolidin-1-yl]-1,4-dioxido-3-phenylquinoxaline-1,4-diium-2-carbonitrile
Molecular FormulaC19H17N5O2
Molecular Weight347.4
XLogP0.3
Topological Polar Surface Area104
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count26
Formal Charge0
Complexity545
SMILES
C1CN(C[C@H]1N)C2=CC3=C(C=C2)[N+](=C(C(=[N+]3[O-])C#N)C4=CC=CC=C4)[O-]
InChI
InChI=1S/C19H17N5O2/c20-11-18-19(13-4-2-1-3-5-13)24(26)16-7-6-15(10-17(16)23(18)25)22-9-8-14(21)12-22/h1-7,10,14H,8-9,12,21H2/t14-/m0/s1
InChIKey
DDDMESNHGOXYCW-AWEZNQCLSA-N
Chemical Structure
2D Structure
2D structure of Hif-1|A-IN-3
CAS: 2170715-64-5
CID: 142770680
Formula: C19H17N5O2
MW: 347.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight347.4
XLogP30.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass347.13822480
Monoisotopic Mass347.13822480
Topological Polar Surface Area104 Ų
Heavy Atom Count26
Formal Charge0
Complexity545
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-124079HIF-1/2α-IN-3
HY-146144-01HIF-IN-1
HY-153020HIF-PHD-IN-3
HY-18370-01HIF-2α-IN-3
HY-19949-01HIF-2α-IN-1
HY-151465-01HIF-1α-IN-4
HY-175521HIF-1α-IN-8
HY-131346-01HIF-PHD-IN-1
HY-149635HIF-1α-IN-6
HY-163370HIF-1α-IN-7

Alternative Products

CatalogName
T61161-01HIF-1α-IN-3
M35415-01HIF-IN-1
PA1041-SHIF-1α
M32959-01HIF-2α-IN-3
MBS5817021HIF-PHD-IN-3
523840-01HIF-3 alpha
BUP04964-01HIF-2a-IN-3

Popular Products