HIF-1α-IN-6

• UNSPSC Description:

  HIF-1α-IN-6 (compound 3s) is a HIF-1α inhibitor with IC50 values of 0.6 and 53.3 nM observed in MiaPaCa-2 and MDA-MB-231 cells. HIF-1α-IN-6 can inhibit HIF-1α expression by decreasing the level of HIF-1α mRNA[1].

• Target Antigen:

  HIF/HIF Prolyl-Hydroxylase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hif-1α-in-6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=NC2=CC(OC)=CC=C2C(NC3=CC=CC(N4CCCC4)=C3)=C1

• Molecular Weight:

  333.43

• References & Citations:

  [1]Edmund I Graziani, et al. PF-06804103, A Site-specific Anti-HER2 Antibody-Drug Conjugate for the Treatment of HER2-expressing Breast, Gastric, and Lung Cancers. Mol Cancer Ther. 2020, 19, 10.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported