PROTAC Mcl1 degrader-1

PROTAC Mcl1 degrader-1

• CAS Number: 2163793-38-0
• UNSPSC Description: PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively Mcl-1 (Bcl-2 family member) inhibitor with an IC50 of 0.78 μM. PROTAC Mcl1 degrader-1 inhibits Bcl-2 with an IC50 of 0.54 μM[1].
• Target Antigen: Bcl-2 Family; PROTACs
• Type: Reference compound
• Related Pathways: Apoptosis;PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mcl1-in-14.html
• Purity: 98.13
• Solubility: DMSO : 50 mg/mL (ultrasonic)
• Smiles: O=C(C1=CC=CC(NCCCCCCNC(CCCCC(NCCN2C(C3=C4C(C2=O)=CC=C(C4=CC=C3)SC5=CC=C(C=C5)Br)=O)=O)=O)=C1C6=O)N6C7CCC(NC7=O)=O
• Molecular Weight: 909.84
• References & Citations: [1]Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, stored under nitrogen)
• Clinical Information: No Development Reported