Keap1-Nrf2-IN-13

Keap1-Nrf2-IN-13

• CAS Number: 2456294-92-9
• UNSPSC Description: Keap1-Nrf2-IN-13 is a Keap1-Nrf2 protein–protein interaction (PPI) inhibitor with an IC50 value of 0.15 μM. Keap1-Nrf2-IN-13 has strong binding affinities to the Keap1 protein by forming hydrogen bond with the key polar residues (Asn414, Arg415, Arg483, Gln530). Keap1-Nrf2-IN-13 can be used in the research of oxidative stress-related and inflammatory diseases, including pulmonary fibrosis, chronic obstructive pulmonary disorder (COPD) and cancers[1].
• Target Antigen: Keap1-Nrf2
• Type: Reference compound
• Related Pathways: NF-κB
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/keap1-nrf2-in-13.html
• Solubility: DMSO : 300 mg/mL (ultrasonic)
• Smiles: O=S(N([C@@H](C)C(O)=O)CC1=CC=CC=C1CN([C@@H](C)C(O)=O)S(=O)(C2=CC=C(OC)C=C2)=O)(C3=CC=C(OC)C=C3)=O
• Molecular Weight: 620.69
• References & Citations: [1][1] Dhulfiqar Ali Abed, et al. Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction. Bioorg Med Chem. 2020 Mar 15;28(6):115343.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported