FBPase-IN-1
CAT:
804-HY-146725-05
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
FBPase-IN-1
- CAS Number: 20362-54-3
- UNSPSC Description: FBPase-IN-1 is a potent FBPase (Fructose-1,6-bisphosphatase) inhibitor for Type 2 diabetes (T2D) study with an IC50 of 0.22 μM. FBPase-IN-1 can reduce blood glucose levels and ameliorate glucose tolerance. FBPase-IN-1 modifies the C128 site, regulates the N125-S124-S123 allosteric pathway of FBPase and affects the catalytic activity of FBPase[1].
- Target Antigen: FBPase
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease
- Applications: Metabolism-sugar/lipid metabolism
- Field of Research: Metabolic Disease
- Assay Protocol: https://www.medchemexpress.com/fbpase-in-1.html
- Solubility: DMSO : 50 mg/mL (ultrasonic)
- Smiles: C1(SSC2=NC=CS2)=NC=CS1
- Molecular Weight: 232.37
- References & Citations: [1]Xu YX, Huang YY, Song RR, et al. Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes. Eur J Med Chem. 2020; 203: 112500.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported