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FBPase-IN-1

CAT: 0804-HY-146725-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-146725-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FBPase-IN-1 is a potent FBPase (Fructose-1,6-bisphosphatase) inhibitor for Type 2 diabetes (T2D) study with an IC50 of 0.22 μM. FBPase-IN-1 can reduce blood glucose levels and ameliorate glucose tolerance. FBPase-IN-1 modifies the C128 site, regulates the N125-S124-S123 allosteric pathway of FBPase and affects the catalytic activity of FBPase[1].
CAS Number
20362-54-3
UNSPSC
12352005
Target
FBPase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/fbpase-in-1.html
Purity
98.30
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C1(SSC2=NC=CS2)=NC=CS1
Molecular Formula
C6H4N2S4
Molecular Weight
232.37
References & Citations
[1]Xu YX, Huang YY, Song RR, et al. Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes. Eur J Med Chem. 2020; 203: 112500.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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