FBPase-IN-2

• Description:

  FBPase-IN-2 (HS36) is a potent Fructose-1,6-bisphosphatase (FBPase) covalent inhibitor with an IC50 of 0.15 μM. FBPase-IN-2 reduces glucose production in hepatocytes. FBPase-IN-2 can be used for type 2 diabetes mellitus research[1].

• UNSPSC:

  12352005

• Target:

  FBPase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/fbpase-in-2.html

• Concentration:

  10mM

• Purity:

  98.47

• Solubility:

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=[N+](C1=CC=C(C=C1)/C=C([N+]([O-])=O)\Cl)[O-]

• Molecular Formula:

  C8H5ClN2O4

• Molecular Weight:

  228.59

• References & Citations:

  [1]Han X, et al. Biological evaluation and SAR analysis of novel covalent inhibitors against fructose-1,6-bisphosphatase. Bioorg Med Chem. 2020 Sep 15;28 (18) :115624.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [127143-25-3]