IU1-248

• Description :

  IU1-248, a derivative of IU1, is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H312, H315, H319, H332, H335

• Target :

  Deubiquitinase

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/iu1-248.html

• Purity :

  99.19

• Solubility :

  DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  N#CC1=CC=C(N2C(C)=C(C(CN3CCC(O)CC3)=O)C=C2C)C=C1

• Molecular Formula :

  C20H23N3O2

• Molecular Weight :

  337.42

• Precautions :

  H302, H312, H315, H319, H332, H335

• References & Citations :

  [1]Yiwei Wang, et al. Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res. 2018 Dec;28 (12) :1186-1194.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2307472-03-1]