AC-4-248

CAT: 0804-HY-161913Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-161913Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

AC-4-248 is an atypical non-competitive dopamine transporter (DAT) inhibitor and reduces the potency of cocaine to inhibit DAT. AC-4-248 is a non-selective inhibitor of SLC6 transporters with IC50 values for hDAT, hSERT, and hNET of 45.5 μM, 96.2 μM, and 250 μM, respectively[1].

UNSPSC

12352005

Target

Dopamine Transporter

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ac-4-248.html

Smiles

ClC1=CC=C(NC2=C3CCN(CCCNC(CCC)=O)C2)C3=C1

Molecular Formula

C18H24ClN3O

Molecular Weight

333.86

References & Citations

[1]Clara Nautrup Pedersen, et al. Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site. J Neurochem. 2024 Jul 15.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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GTR19238071-01	AC-4-248
BA3895-10	IU1-248
440715-01	AC 4
T26540-01	AC-4
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RM-T140848-01	Tenofovir Impurity 248
RM-F260248-01	Finerenone Impurity 248
RM-A162648-01	Apixaban Impurity 248
MBS5823202	PAP 248-286
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AC-4-248

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