IU1

• Description :

  IU1 is a special Usp14 inhibitor with an IC50 of 4-5 μM.

• CAS Number :

  [314245-33-5]

• UNSPSC :

  12352005

• Hazard Statement :

  H318

• Target :

  Autophagy; Deubiquitinase

• Type :

  Reference compound

• Related Pathways :

  Autophagy; Cell Cycle/DNA Damage

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/IU1.html

• Purity :

  99.30

• Solubility :

  DMSO : 41.67 mg/mL (ultrasonic)

• Smiles :

  CC1=CC(C(CN2CCCC2)=O)=C(C)N1C3=CC=C(F)C=C3

• Molecular Formula :

  C18H21FN2O

• Molecular Weight :

  300.37

• Precautions :

  H318

• References & Citations :

  [1]Lee BH, et al. Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature. 2010 Sep 9;467 (7312) :179-84.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported