Products for Research Use Only
RegisterLogin

JAB-2485

CAT: 0804-HY-157396-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-157396-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
JAB-2485 is an orally active and selective Aurora kinase A (AURKA) inhibitor with an IC50 value of 0.327 nM. JAB-2485 exhibits inhibitory activity against various tumor cell lines such as neuroblastoma, triple-negative breast cancer, small cell lung cancer, and epithelial ovarian cancer. JAB-2485 can induce cell cycle arrest and apoptosis in tumor cells. JAB-2485 has antitumor activity[1][2].
CAS Number
2899209-55-1
UNSPSC
12352005
Target
Apoptosis; Aurora Kinase; Caspase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jab-2485.html
Purity
98.11
Solubility
DMSO : ≥ 100 mg/mL
Smiles
ClC1=CC=CC(CN2CC[C@](C(O)=O)(CC3=CC(C)=C(F)C(NC4=CC(C)=NN4)=N3)C[C@H]2C)=C1F
Molecular Formula
C25H28ClF2N5O2
Molecular Weight
503.97
References & Citations
[1]Yang G, et, al. Abstract 1645: JAB-2485: A potent, highly selective small-molecule Aurora kinase A inhibitor that targets cell division. Cancer Res (2023) 83 (7_Supplement) : 1645.|[2]Yang G, et al. Preclinical Evaluation of JAB-2485, a Potent AURKA Inhibitor with High Selectivity and Favorable Pharmacokinetic Properties. ACS Omega. 2024 May 3;9 (19) :21416-21425.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Aurora A; Caspase 3; Caspase 7

Related Products

CatalogName
HY-P991332JAB-BX102
HY-131132-01JAB-3068
HY-131132A-01JAB-3068 (hydrochloride)
HY-10313ZD 2486
HY-122885-01IU1-248
HY-12184-01ONO-AE 248
HY-P5363PAP 248-286
HY-W999622CRBN ligand-248
HY-W681949-01Antibacterial agent 248
HY-161913AC-4-248

Alternative Products

CatalogName
BA3077-5JAB-2485
A24086-10JAB-2485 10mg
A24086-1JAB-2485 1mg
A24086-50JAB-2485 50mg
A24086-5JAB-2485 5mg
MBS3606228MRS 2485
MBS5783879RO-48-2485
T9901A-1071-01JAB-BX102
C01517-100mgJAB-3068
E4705-01JAB-3312

Popular Products