MK-0434

• UNSPSC Description:

  MK-0434 is an orally active steroid 5α-reductase inhibitor. MK-0434 specifically inhibits steroid 5α-reductase, thereby reducing the level of dihydrotestosterone (DHT) in the body. MK-0434 can be used in the study of benign prostatic hyperplasia[1].

• Target Antigen:

  5 alpha Reductase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/mk-0434.html

• Smiles:

  C[C@@]12[C@H](CC[C@]1([C@@]3(CC[C@]4(NC(C=C[C@@]4([C@]3(CC2)[H])C)=O)[H])[H])[H])C(C5=CC=CC=C5)=O

• Molecular Weight:

  377.52

• References & Citations:

  [1]Van Hecken, et al. "Plasma concentrations and effect on testosterone metabolism after single doses of MK-0434, a steroid 5 alpha-reductase inhibitor, in healthy subjects." European journal of clinical pharmacology 46 (1994): 123-126.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 1

• CAS Number:

  134067-56-4