MK-0434

• Description :

  MK-0434 is an orally active steroid 5α-reductase inhibitor. MK-0434 specifically inhibits steroid 5α-reductase, thereby reducing the level of dihydrotestosterone (DHT) in the body. MK-0434 can be used in the study of benign prostatic hyperplasia[1].

• UNSPSC :

  12352005

• Target :

  5 alpha Reductase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/mk-0434.html

• Smiles :

  C[C@@]12[C@H](CC[C@]1([C@@]3(CC[C@]4(NC(C=C[C@@]4([C@]3(CC2)[H])C)=O)[H])[H])[H])C(C5=CC=CC=C5)=O

• Molecular Formula :

  C25H31NO2

• Molecular Weight :

  377.52

• References & Citations :

  [1]Van Hecken, et al. "Plasma concentrations and effect on testosterone metabolism after single doses of MK-0434, a steroid 5 alpha-reductase inhibitor, in healthy subjects." European journal of clinical pharmacology 46 (1994) : 123-126.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [134067-56-4]