NU-8165

• Description:

  NU-8165 is an inhibitor of the MDM2-p53 protein-protein interaction with anti-tumor activity. Optimization of NU-8165 was guided by MDM2 NMR titrations, which indicated key binding interaction regions. NU-8165 activated MDM2 and p21 transcription in cell-based assays and showed modest selectivity for wild-type p53 cell lines[1].

• UNSPSC:

  12352005

• Target:

  MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nu-8165.html

• Smiles:

  O=C1N(CC2=CC=CC=C2)C(OCCCO)(C3=CC=C(Cl)C=C3)C4=C1C=CC=C4

• Molecular Formula:

  C24H22ClNO3

• Molecular Weight:

  407.89

• References & Citations:

  [1]Isoindolinone inhibitors of the murine double minute 2 (MDM2) -p53 protein-protein interaction: structure-activity studies leading to improved potency

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  849723-20-2