RegisterLogin

NU-8165

CAT: 0804-HY-122038Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-122038Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
NU-8165 is an inhibitor of the MDM2-p53 protein-protein interaction with anti-tumor activity. Optimization of NU-8165 was guided by MDM2 NMR titrations, which indicated key binding interaction regions. NU-8165 activated MDM2 and p21 transcription in cell-based assays and showed modest selectivity for wild-type p53 cell lines[1].
CAS Number
[849723-20-2]
UNSPSC
12352005
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nu-8165.html
Smiles
O=C1N(CC2=CC=CC=C2)C(OCCCO)(C3=CC=C(Cl)C=C3)C4=C1C=CC=C4
Molecular Formula
C24H22ClNO3
Molecular Weight
407.89
References & Citations
[1]Isoindolinone inhibitors of the murine double minute 2 (MDM2) -p53 protein-protein interaction: structure-activity studies leading to improved potency
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-120452AZD-8165
HY-100569NU-3
HY-116621NU-7163
HY-15719-01NU 7026
HY-14206NU 1085
HY-174351NU-PRO-1
HY-118379NU/ICRF 500
HY-P73699PRKD3/nPKC nu, Human (sf9, GST)
HY-158374BIO-8169
HY-156962-01BFF-816

Alternative Products

CatalogName
T24560-01NU-8165
MBS3600725-01AZD-8165
M33896-01NU 9056
T68691-01NU-7031
T24561-01NU-8231
3301/10NU 6140
TRC-N925300-10MGNU 7441
MBS131771NU 2058
27312NU 7026
B1117-25NU-7441

Popular Products