NU-8165

• Description :

  NU-8165 is an inhibitor of the MDM2-p53 protein-protein interaction with anti-tumor activity. Optimization of NU-8165 was guided by MDM2 NMR titrations, which indicated key binding interaction regions. NU-8165 activated MDM2 and p21 transcription in cell-based assays and showed modest selectivity for wild-type p53 cell lines[1].

• UNSPSC :

  12352005

• Target :

  MDM-2/p53

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/nu-8165.html

• Smiles :

  O=C1N(CC2=CC=CC=C2)C(OCCCO)(C3=CC=C(Cl)C=C3)C4=C1C=CC=C4

• Molecular Formula :

  C24H22ClNO3

• Molecular Weight :

  407.89

• References & Citations :

  [1]Isoindolinone inhibitors of the murine double minute 2 (MDM2) -p53 protein-protein interaction: structure-activity studies leading to improved potency

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [849723-20-2]