NU-PRO-1

CAT: 0804-HY-174351Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-174351Size:1 Each
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Description
NU-PRO-1 is a covalent Telomerase reverse transcriptase (TERT) PROTAC degrader. NU-PRO-1 dose not induce DNA damage on its own but acts to further delay DNA repair after irradiation[1]. Pink: TERT ligand (HY-174352) ; Blue: VHL ligase ligand (HY-125845) ; Black: linker (HY-W005056)
UNSPSC
12352005
Target
PROTACs; Telomerase
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Field of Research
Cancer
Smiles
O=C([C@](C1=O)(C)[C@H](CCC2=CN(CC3=CC(C(NCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=C(F)C=C3F)N=N2)O[C@H](C)C1=C)OC
Molecular Formula
C50H62F2N8O11S
Molecular Weight
1021.14
References & Citations
[1]Frost GB, et al. Telomerase reverse transcriptase degradation via a rationally designed covalent proteolysis targeting chimera. Bioorg Med Chem Lett. 2025 Sep 1;125-126:130286.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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