NU-PRO-1

• Description:

  NU-PRO-1 is a covalent Telomerase reverse transcriptase (TERT) PROTAC degrader. NU-PRO-1 dose not induce DNA damage on its own but acts to further delay DNA repair after irradiation[1]. Pink: TERT ligand (HY-174352) ; Blue: VHL ligase ligand (HY-125845) ; Black: linker (HY-W005056)

• UNSPSC:

  12352005

• Target:

  PROTACs; Telomerase

• Related Pathways:

  Cell Cycle/DNA Damage; PROTAC

• Field of Research:

  Cancer

• Smiles:

  O=C([C@](C1=O)(C)[C@H](CCC2=CN(CC3=CC(C(NCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=C(F)C=C3F)N=N2)O[C@H](C)C1=C)OC

• Molecular Formula:

  C50H62F2N8O11S

• Molecular Weight:

  1021.14

• References & Citations:

  [1]Frost GB, et al. Telomerase reverse transcriptase degradation via a rationally designed covalent proteolysis targeting chimera. Bioorg Med Chem Lett. 2025 Sep 1;125-126:130286.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported