NU 1085

• Description :

  NU 1085 is a potent poly (ADP-ribose) polymerase (PARP) inhibitor with a Ki of 6 nM. NU 1085 shows strong cytotoxicity to cancer cells (LC50 = 83-94 μM) and can enhance the anticancer effect of Temozolomide (HY-17364) . NU 1085 can be used for the research of cancer, such as lung cancer[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319

• Target :

  PARP

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics

• Field of Research :

  Cancer

• Smiles :

  NC(C1=C2C(NC(C3=CC=C(O)C=C3)=N2)=CC=C1)=O

• Molecular Formula :

  C14H11N3O2

• Molecular Weight :

  253.26

• Precautions :

  P264-P270-P280-P302+P352-P330-P362+P364-P501

• References & Citations :

  [1]Delaney CA, et al. Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly (adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin Cancer Res. 2000 Jul;6 (7) :2860-7.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [188106-83-4]