NU 1085

• Description:

  NU 1085 is a potent poly (ADP-ribose) polymerase (PARP) inhibitor with a Ki of 6 nM. NU 1085 shows strong cytotoxicity to cancer cells (LC50 = 83-94 μM) and can enhance the anticancer effect of Temozolomide (HY-17364) . NU 1085 can be used for the research of cancer, such as lung cancer[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319

• Target:

  PARP

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Field of Research:

  Cancer

• Smiles:

  NC(C1=C2C(NC(C3=CC=C(O)C=C3)=N2)=CC=C1)=O

• Molecular Formula:

  C14H11N3O2

• Molecular Weight:

  253.26

• Precautions:

  P264-P270-P280-P302+P352-P330-P362+P364-P501

• References & Citations:

  [1]Delaney CA, et al. Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly (adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin Cancer Res. 2000 Jul;6 (7) :2860-7.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [188106-83-4]