WDR5-IN-4 (TFA)
CAT:
804-HY-111753A-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
WDR5-IN-4 (TFA)
- CAS Number: 2749300-35-2
- UNSPSC Description: WDR5-IN-4 TFA is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. WDR5-IN-4 TFA displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity[1].
- Target Antigen: Histone Methyltransferase
- Type: Reference compound
- Related Pathways: Epigenetics
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/win-site-inhibitor-1-tfa.html
- Purity: 99.87
- Solubility: DMSO : ≥ 250 mg/mL
- Smiles: ClC1=CC=C(CNC(C2=CC(CN3C(N(C)C=C3)=N)=CC(C4=C(C)N=C(F)C=C4)=C2)=O)C=C1Cl.O=C(O)C(F)(F)F
- Molecular Weight: 612.40
- References & Citations: [1]Aho ER, et al. Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13.bioRxiv. 2023 Dec 16.|bioRxiv. 2023 Jun 5.|Cell Rep. 2023 Apr 21;42(5):112423.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, stored under nitrogen, away from moisture)
- Clinical Information: No Development Reported