WDR5-IN-1

WDR5-IN-1

• CAS Number: 2408842-51-1
• UNSPSC Description: WDR5-IN-1 is a potent and selective WD repeat domain 5 (WDR5) inhibitor, with a Kd of 50 of 2.2 nM. WDR5-IN-1 diminishes MYC recruitment at WDR5-displaced genes and exhibits potent anti-proliferative effects in CHP-134 (neuroblastoma) and Ramos (Burkitt’s lymphoma) lines[1].
• Target Antigen: Apoptosis; Histone Methyltransferase
• Type: Reference compound
• Related Pathways: Apoptosis;Epigenetics
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/wdr5-in-1.html
• Smiles: COC1=CC(OC)=CC(CN2C(C(C=C(CN3C(N(C)C=C3)=N)C=C4C5=C(C)C=C(F)C=C5)=C4CC2)=O)=C1
• Molecular Weight: 514.59
• References & Citations: [1]Tian J, et al.Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.J Med Chem. 2020 Jan 23;63(2):656-675.
• Shipping Conditions: Room Temperature