WDR5-IN-5

• Description :

  WDR5-IN-5 is an orally active and selective inhibitor of WIN site of WD repeat domain 5 (WDR5) . WDR5-IN-5 exhibits anti-proliferative activity towards cancer cells and good pharmacokinetics profile in mice. WDR5-IN-5 shows high affinity to WDR5 and the binding affinity Ki value [1].

• UNSPSC :

  12352005

• Target :

  WDR5

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/wdr5-in-5.html

• Purity :

  99.56

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1N([C@@H](C2CC2)C3=NC=CC(C)=C3)CCC4=C1C=C(CN5C=CN=C5)C=C4C6=CN(CC)N=C6C(F)(F)F

• Molecular Formula :

  C29H29F3N6O

• Molecular Weight :

  534.58

• References & Citations :

  [1]Teuscher KB, et al. Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization. J Med Chem. 2022 Apr 28. 65 (8) :6287-6312.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2417012-26-9]