WDR5-IN-4

WDR5-IN-4

• CAS Number: 2407457-36-5
• UNSPSC Description: WDR5-IN-4 is a WIN site inhibitor of chromatin-associated WD repeat domain 5 protein (WDR5), Kd The value is 0.1 nM. WDR5-IN-4 is able to displace WDR5 from chromatin and reduce the expression of related genes, causing translation inhibition and nucleolar stress. Has anti-cancer effects [1][1].
• Target Antigen: Histone Methyltransferase
• Type: Reference compound
• Related Pathways: Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/WIN_site_inhibitor_1.html
• Purity: 98.13
• Solubility: 10 mM in DMSO
• Smiles: ClC1=CC=C(CNC(C2=CC(CN3C(N(C)C=C3)=N)=CC(C4=C(C)N=C(F)C=C4)=C2)=O)C=C1Cl
• Molecular Weight: 498.38
• References & Citations: [1]Aho ER, et al. Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13.Cell Rep. 2023 Apr 21;42(5):112423.|bioRxiv. 2023 Dec 16.|bioRxiv. 2023 Jun 5.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported