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NIC-0102

CAT: 0804-HY-151252-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-151252-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NIC-0102 is an orally active proteasome inhibitor (pIC50=7.55) that specifically inhibits NLRP3 inflammatory vesicle activation. NIC-0102 shows potent anti-inflammatory effects in a model of dextran sulfate sodium (DSS) -induced ulcerative colitis. NIC-0102 also inhibits production of pro-IL-1β[1].
CAS Number
[2806031-94-5]
UNSPSC
12352005
Target
NOD-like Receptor (NLR) ; Proteasome
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nic-0102.html
Purity
98.72
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C[C@@H](B(O)O)NC([C@@H](NC(C1=C(C=CC=C1F)F)=O)CC2=CC=CC=C2)=O)C
Molecular Formula
C21H25BF2N2O4
Molecular Weight
418.24
References & Citations
[1]Wu X, et al. Discovery of a Novel Oral Proteasome Inhibitor to Block NLRP3 Inflammasome Activation with Anti-inflammation Activity. J Med Chem. 2022 Sep 5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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