NIC-12

• Target :

  NOD-like Receptor (NLR)

• Related Pathways :

  Immunology/Inflammation

• Bioactivity :

  NIC-12, a potent NLRP3 inhibitor, selectively reduces circulating IL-1ß levels in the LPS-endotoxemia mice model and inhibits NLRP3 inflammasome activation in mouse macrophages [1].

• Smiles :

  C(C)(C)C=1N2C3=C(C=C2C(=O)N(CC(N[C@H]4CN(CC5CC5)CCC4)=O)N1)SC(Cl)=C3

• Molecular Formula :

  C22H28ClN5O2S

• Molecular Weight :

  462.01

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2409826-23-7