NICE-01

• Description :

  NICE-01 (AP1867-PEG2-JQ1; AP-PEG2-JQ1) is a bifunctional compound that bind to proteins in separate cellular compartments that can induce nuclear import of cytosolic cargoes, using nuclear-localized bromodomain-containing protein 4 (BRD4) as a “carrier” for co-import and nuclear trapping of cytosolic proteins[1].

• Product Name Alternative :

  AP1867-PEG2-JQ1; AP-PEG2-JQ1

• UNSPSC :

  12352005

• Target :

  Epigenetic Reader Domain

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/nice-01.html

• Purity :

  99.53

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC(C(C(C(C=C1)=CC=C1Cl)=N[C@H]2CC(NCCOCCOCCNC(COC3=CC([C@@H](CCC(C=C4)=CC(OC)=C4OC)OC([C@H](CCCC5)N5C([C@H](C(C=C6OC)=CC(OC)=C6OC)CC)=O)=O)=CC=C3)=O)=O)=C(S7)N8C2=NN=C8C)=C7C

• Molecular Formula :

  C63H76ClN7O13S

• Molecular Weight :

  1206.83

• References & Citations :

  [1]William J. Gibson, et al. Bifunctional small molecules that induce nuclear localization and targeted transcriptional regulation. Version 1. bioRxiv. Preprint. 2023 Jul 7.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2982819-94-1]