JC-010a

• Description :

  JC-010a is a selective SHP2 allosteric inhibitor. JC-010a inhibits cancer cells proliferation. JC-010a can be used for the research of cancer[1].

• CAS Number :

  [2565765-13-9]

• UNSPSC :

  12352005

• Target :

  Apoptosis; SHP2

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/jc-010a.html

• Solubility :

  10 mM in DMSO

• Smiles :

  ClC1=CC=CC(C2=NC(N=CC(N3CCC4(CC5=CC=CC=C5[C@H]4N)CC3)=N6)=C6S2)=C1Cl

• Molecular Formula :

  C24H21Cl2N5S

• Molecular Weight :

  482.43

• References & Citations :

  [1]Lu X, et al. JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers. Cancer Lett. 2024 Feb 1;582:216517.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported