JC-010a

CAT: 0804-HY-157507Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-157507Size:1 Each
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Description
JC-010a is a selective SHP2 allosteric inhibitor. JC-010a inhibits cancer cells proliferation. JC-010a can be used for the research of cancer[1].
CAS Number
[2565765-13-9]
UNSPSC
12352005
Target
Apoptosis; SHP2
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jc-010a.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=CC(C2=NC(N=CC(N3CCC4(CC5=CC=CC=C5[C@H]4N)CC3)=N6)=C6S2)=C1Cl
Molecular Formula
C24H21Cl2N5S
Molecular Weight
482.43
References & Citations
[1]Lu X, et al. JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers. Cancer Lett. 2024 Feb 1;582:216517.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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