MB-07344

• Description :

  MB-07344 is a potent thyroid hormone receptor (TR) -β agonist with a Ki of 2.17 nM. MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin (HY-B0589) in rabbits, dogs and monkeys[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Thyroid Hormone Receptor

• Type :

  Reference compound

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/mb-07344.html

• Purity :

  99.86

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  CC1=C(CC2=CC=C(O)C(C(C)C)=C2)C(C)=CC(OCP(O)(O)=O)=C1

• Molecular Formula :

  C19H25O5P

• Molecular Weight :

  364.37

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Ito BR, et al. Thyroid hormone beta receptor activation has additive cholesterol lowering activity in combination with atorvastatin in rabbits, dogs and monkeys. Br J Pharmacol. 2009 Feb;156 (3) :454-65.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [852947-39-8]