MB-07803

• Description :

  MB07803 is an orally available prodrug of a potent, noncompetitive inhibitor (MB07729) of fructose 1,6-bisphosphatase (FBPase), with EC50 of 140 nM and t1/2 of 7.6±2.9 h.

• CAS Number :

  [882757-24-6]

• UNSPSC :

  12352005

• Target :

  Phosphatase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/MB-07803.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C(C)(C)NP(NC(C)(C)C(OCC)=O)(C1=CC=C(C2=C(C(C(C)(C)C)=O)SC(N)=N2)O1)=O)OCC

• Molecular Formula :

  C24H37N4O7PS

• Molecular Weight :

  556.61

• References & Citations :

  [1]van Poelje PD, et al. Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes. Handb Exp Pharmacol. 2011; (203) :279-301.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2