MB-Buf

• Description :

  MB-Buf is a conjugation of methylene blue (HY-14536) and bufalin (HY-N0877) . MB-Buf can targeting degrade GPX4 upon light activation. MB-Buf can induce cell apoptosis, ferroptosis, and ROS production. MB-Buf can be used for the research of cancer, such as breast cancer[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Ferroptosis; Glutathione Peroxidase; Reactive Oxygen Species (ROS)

• Related Pathways :

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O[C@]([C@@](CC[C@@]1([H])[C@@]2(CC[C@H](OC(CC/N=C3C=C4SC5=CC(N(CC)CC)=CC=C5N=C4C6=CC=CC=C/36)=O)C1)C)([H])[C@]2([H])CC7)(CC[C@@H]8C(C=C9)=COC9=O)[C@]78C

• Molecular Formula :

  C47H55N3O5S

• Molecular Weight :

  774.02

• References & Citations :

  [1]Mo X, et al. Design of photoactivatable methylene blue-bufalin conjugate for GPX4-targeted degradation to induce ferroptosis-like death in breast cancer therapy. Bioorg Chem. 2025 Aug;163:108629.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  GPX4