ABTL-0812

• Description:

  ABTL-0812 (α-Hydroxylinoleic acid) induces endoplasmic reticulum (ER) stress-mediated autophagy. ABTL-0812 is a first-in-class small molecule with anti-cancer activity[1].

• Product Name Alternative:

  α-Hydroxylinoleic acid

• UNSPSC:

  12352211

• Target:

  Autophagy

• Type:

  Natural Products

• Related Pathways:

  Autophagy

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/_alpha_-Hydroxylinoleic_acid.html

• Purity:

  99.84

• Solubility:

  DMSO : 90 mg/mL (ultrasonic)

• Smiles:

  CCCCC/C=C\C/C=C\CCCCCCC(O)C(O)=O

• Molecular Formula:

  C18H32O3

• Molecular Weight:

  296.44

• References & Citations:

  [1]Muñoz-Guardiola P, et al. The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells. Autophagy. 2020 May 13.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Phase 2

• CAS Number:

  [57818-44-7]