Products for Research Use Only
RegisterLogin

(+) -JJ-74-138

CAT: 0804-HY-164371Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-164371Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
(+) -JJ-74-138, a novel non-competitive androgen receptor (AR) antagonist, is capable of inhibiting Enzalutamide-resistant CRPC[1].
CAS Number
2135545-34-3
UNSPSC
12352005
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/plus-jj-74-138.html
Smiles
O=C(N1CCN(C2=CC(C(F)(F)F)=CC=C2C)CC1)[C@H]3[C@@H](C4=CC(S(F)(F)(F)(F)F)=CC=C4)C3
Molecular Formula
C22H22F8N2OS
Molecular Weight
514.48
References & Citations
[1] (+) -JJ-74-138 is a Novel Noncompetitive Androgen Receptor Antagonist. Mol Cancer Ther. 2022 Apr 1;21 (4) :483-492.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

[4-[2-methyl-5-(trifluoromethyl)phenyl]piperazin-1-yl]-[(1R,2S)-2-[3-(pentafluoro-lambda6-sulfanyl)phenyl]cyclopropyl]methanone
CAS Number2135545-34-3
PubChem CID130471186
IUPAC Name[4-[2-methyl-5-(trifluoromethyl)phenyl]piperazin-1-yl]-[(1R,2S)-2-[3-(pentafluoro-lambda6-sulfanyl)phenyl]cyclopropyl]methanone
Molecular FormulaC22H22F8N2OS
Molecular Weight514.5
XLogP7.7
Topological Polar Surface Area24.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count10
Rotatable Bond Count3
Heavy Atom Count34
Formal Charge0
Complexity780
SMILES
CC1=C(C=C(C=C1)C(F)(F)F)N2CCN(CC2)C(=O)[C@@H]3C[C@@H]3C4=CC(=CC=C4)S(F)(F)(F)(F)F
InChI
InChI=1S/C22H22F8N2OS/c1-14-5-6-16(22(23,24)25)12-20(14)31-7-9-32(10-8-31)21(33)19-13-18(19)15-3-2-4-17(11-15)34(26,27,28,29)30/h2-6,11-12,18-19H,7-10,13H2,1H3/t18-,19-/m1/s1
InChIKey
YLXDFZCDJOWDSY-RTBURBONSA-N
Chemical Structure
2D Structure
2D structure of [4-[2-methyl-5-(trifluoromethyl)phenyl]piperazin-1-yl]-[(1R,2S)-2-[3-(pentafluoro-lambda6-sulfanyl)phenyl]cyclopropyl]methanone
CAS: 2135545-34-3
CID: 130471186
Formula: C22H22F8N2OS
MW: 514.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight514.5
XLogP37.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count10
Rotatable Bond Count3
Exact Mass514.13250980
Monoisotopic Mass514.13250980
Topological Polar Surface Area24.6 Ų
Heavy Atom Count34
Formal Charge0
Complexity780
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-403733CJJ-450
HY-403733A(–) -JJ-450
HY-403733B(+) -JJ-450
HY-163098JJ-OX-007
HY-153365-01I-138
HY-169428EGFR-IN-138
HY-113738ADN 138
HY-157723HSD17B13-IN-74
HY-173294NLRP3-IN-74
HY-P5260Oligopeptide-74

Alternative Products

CatalogName
T200319-01(+) -JJ-74-138
T211772-01(-) -JJ-450
T211013-01(+) -JJ-450
GTR19264068-01JJ-450
sc-81866NOP16 (JJ-39)
sc-101205SAV1 (JJ-6)
T208850-01JJ-OX-007
sc-100966LUCA15 (17-JJ)
sc-81971MOX-2 (JJ-7)
sc-53595KIR2DL1 (JJ C11.6)

Popular Products