ADN 138

• Description :

  ADN-138 is an aldose reductase inhibitor. ADN-138 reduces sorbitol levels in diabetic nerves and results in significant increases in MNCV and Na+, K+-ATPase in the nerves. ADN-138 can be used in the research of diabetic nerve complications[1].

• UNSPSC :

  12352005

• Target :

  Aldose Reductase; Endogenous Metabolite; Na+/K+ ATPase

• Related Pathways :

  Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

• Field of Research :

  Metabolic Disease; Neurological Disease

• Smiles :

  O=C(N1)C2(CC1=O)C3=C4N(CCOC4=CC(Cl)=C3)C2=O

• Molecular Formula :

  C13H9ClN2O4

• Molecular Weight :

  292.67

• References & Citations :

  [1]Hirata Y, Okada K. Relation of Na+, K (+) -ATPase to delayed motor nerve conduction velocity: effect of aldose reductase inhibitor, ADN-138, on Na+, K (+) -ATPase activity. Metabolism. 1990 Jun;39 (6) :563-7.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [99434-90-9]