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NLRP3-IN-74

CAT: 0804-HY-173294Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173294Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NLRP3-IN-74 (Compound 11) is an orally active NLRP3 inhibitor with an IC50 value of 2.7 μM. NLRP3-IN-74 can inhibit the release of IL-1β, reducing the release level by approximately 90%, and does not inhibit the release of TNFα. NLRP3-IN-74 can be used in the research of related diseases such as atherosclerosis and Parkinson's disease[1].
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Field of Research
Neurological Disease; Cardiovascular Disease
Smiles
O=C(N1C2CCN(C([C@@H](C)NC(C3=CC=CO3)=O)=O)CC2)NC4=C1C=CC=C4
Molecular Formula
C20H22N4O4
Molecular Weight
382.41
References & Citations
[1]Dorich S, et al. Discovery of novel NLRP3 inhibitors enabled by a high-throughput screen. Bioorg Med Chem Lett. 2025 Jul 1;122:130184.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3

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