Products for Research Use Only
RegisterLogin

JJ-450

CAT: 0804-HY-403733CSize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-403733CSize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
JJ-450 is a non-competitive antagonist androgen receptor (AR) that inhibits the transcriptional activity of wild-type AR and mutant ARF876L. JJ-450 has an IC50 of approximately 1-10 μM in inhibiting AR transcriptional activity in PC3 cells. It is selective for AR binding and does not compete with androgens for binding to the ligand binding domain (LBD) of AR. JJ-450 inhibits the transcriptional activity of AR and its splice variants (such as ARF876L) by inhibiting AR nuclear translocation and promoting the degradation of unliganded AR in the nucleus. JJ-450 can be used in castration-resistant prostate cancer (CRPC) studies that are resistant to Enzalutamide (MDV3100).
CAS Number
2020353-42-6
UNSPSC
12352005
Target
Androgen Receptor
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
O=C(N1CCN(C2=C(C=CC(Cl)=C2)C)CC1)[C@H]3[C@@H](C4=CC=C(C=C4)F)C3
Molecular Formula
C21H22ClFN2O
Molecular Weight
372.86
References & Citations
[1]Wu Z, et al. A novel androgen receptor antagonist JJ-450 inhibits enzalutamide-resistant mutant ARF876L nuclear import and function. Prostate. 2020 Mar;80 (4) :319-328.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-164371(+) -JJ-74-138
HY-163098JJ-OX-007
HY-W953361CRBN ligand-450
HY-P10635TKD (450-463)
HY-W024297VP-4509
HY-R01120-01Hsa-miR-4506 mimic
HY-RI01114-01Hsa-miR-4500 inhibitor
HY-RI01123-01Hsa-miR-4509 inhibitor
HY-R01121-01Hsa-miR-4507 mimic
HY-R01123A-01Hsa-miR-4509 agomir

Alternative Products

CatalogName
T211772-01(-) -JJ-450
T211013-01(+) -JJ-450
GTR19264068-01JJ-450
sc-81866NOP16 (JJ-39)
T200319-01(+) -JJ-74-138
sc-101205SAV1 (JJ-6)
T208850-01JJ-OX-007
sc-100966LUCA15 (17-JJ)
sc-81971MOX-2 (JJ-7)
sc-53595KIR2DL1 (JJ C11.6)

Popular Products