(-) -JJ-450

• Target:

  Androgen Receptor

• Related Pathways:

  Endocrinology/Hormones

• Bioactivity:

  (-) -JJ-450 is a non-competitive antagonist targeting the androgen receptor (AR) . It is more effective than (+) -JJ-450 in inhibiting androgen-induced AR activity, while (+) -JJ-450 inhibits AR via a mechanism distinct from Enzalutamide (MDV3100), possibly targeting the ligand-binding domain (LBD) of AR. (-) -JJ-450 inhibits transcriptional activity of both wild-type AR and the mutant ARF876L by suppressing AR nuclear translocation and promoting intranuclear degradation of unbound AR. This compound can be utilized in research focusing on castration-resistant prostate cancer (CRPC) that is resistant to Enzalutamide.

• Smiles:

  C(=O)([C@@H]1[C@@H](C1)C2=CC=C(F)C=C2)N3CCN(CC3)C4=C(C)C=CC(Cl)=C4

• Molecular Formula:

  C21H22ClFN2O

• Molecular Weight:

  372.86

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1998094-23-7