T-3364366

• Description :

  T-3364366 is a reversible, slow-binding, thienopyrimidinone delta-5 desaturase (D5D) inhibitor with IC50s of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cells, respectively. T-3364366 exhibits potent D5D (IC500=19 nM) inhibitory activity and excellent selectivity away from delta-6 desaturase (D6D, IC50=6200 nM) and delta-9 desaturase (stearoyl-CoA desaturase, SCD,50 >10000 nM) in the enzymatic activity assay[1].

• UNSPSC :

  12352005

• Target :

  Stearoyl-CoA Desaturase (SCD)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/t-3364366.html

• Purity :

  99.80

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  CC(NCCSC1=NC2=CSC=C2C(N1C3=CC=C(OCC(F)(F)F)C=C3)=O)=O

• Molecular Formula :

  C18H16F3N3O3S2

• Molecular Weight :

  443.46

• References & Citations :

  [1]Ikuo Miyahisa, et al. T-3364366 Targets the Desaturase Domain of Delta-5 Desaturase with Nanomolar Potency and a Multihour Residence Time. ACS Med Chem Lett. 2016 Aug 10;7 (9) :868-72.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1356354-09-0]