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T-3364366

CAT: 0804-HY-124346-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124346-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
T-3364366 is a reversible, slow-binding, thienopyrimidinone delta-5 desaturase (D5D) inhibitor with IC50s of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cells, respectively. T-3364366 exhibits potent D5D (IC500=19 nM) inhibitory activity and excellent selectivity away from delta-6 desaturase (D6D, IC50=6200 nM) and delta-9 desaturase (stearoyl-CoA desaturase, SCD,50 >10000 nM) in the enzymatic activity assay[1].
CAS Number
1356354-09-0
UNSPSC
12352005
Target
Stearoyl-CoA Desaturase (SCD)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/t-3364366.html
Purity
99.80
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC(NCCSC1=NC2=CSC=C2C(N1C3=CC=C(OCC(F)(F)F)C=C3)=O)=O
Molecular Formula
C18H16F3N3O3S2
Molecular Weight
443.46
References & Citations
[1]Ikuo Miyahisa, et al. T-3364366 Targets the Desaturase Domain of Delta-5 Desaturase with Nanomolar Potency and a Multihour Residence Time. ACS Med Chem Lett. 2016 Aug 10;7 (9) :868-72.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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