T-1228

• Description:

  T-1228 is a highly selective LpxC inhibitor. T-1228 can effectively block the synthesis of LPS (HY-D1056), causing defects in the bacterial outer membrane structure, increasing membrane permeability, and ultimately leading to bacterial cell death. T-1228 can be used for the study of Gram-negative bacterial infections[1].

• UNSPSC:

  12352005

• Target:

  Bacterial

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Smiles:

  O=C(N(C)[C@](C(NC)=O)(C)C(NO)=O)C(C=C1)=CC=C1C#CC2=CC=C([C@H](O)CO)C=C2.O

• Molecular Formula:

  C23H27N3O7

• Molecular Weight:

  457.48

• References & Citations:

  [1]Nagato Y, Nakajima N. Process Development of the Novel LpxC Inhibitor T-1228. Part 4: Control of Mutagenic Impurities during API Synthesis. Organic Process Research & Development. 2025 Nov 20.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1884551-35-2]