Thioflavin T

• Description :

  Thioflavin T is a cationic Benzothiazole dye that shows enhanced fluorescence upon binding to amyloid in tissue sections. Excitation max.: ~385 nm (free) ; ~450 nm (bound) ; Emission max.: ~445 nm (free) ; ~485 nm (bound) [1][2][3].

• Product Name Alternative :

  Basic Yellow 1

• UNSPSC :

  12171500

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Amyloid-β

• Type :

  Dye Reagents

• Related Pathways :

  Neuronal Signaling

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/Thioflavin_T.html

• Purity :

  98.23

• Solubility :

  DMSO : 16.67 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  CC1=CC=C2[N+](C)=C(C3=CC=C(N(C)C)C=C3)SC2=C1.[Cl-]

• Molecular Formula :

  C17H19ClN2S

• Molecular Weight :

  318.86

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Khurana R, et al. Mechanism of thioflavin T binding to amyloid fibrils. J Struct Biol. 2005 Sep;151 (3) :229-38.|[2]Nakano H, et al. Globular-shaped Aβ oligomers have diverse mechanisms for promoting Aβ aggregations with the facilitation of fibril elongation. Neurobiol Dis. 2025 Feb;205:106775.|[3]Muramatsu D, et al. ALZ-801 prevents amyloid β-protein assembly and reduces cytotoxicity: A preclinical experimental study. FASEB J. 2025 Feb 15;39 (3) :e70382.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Dye Reagents

• Clinical Information :

  No Development Reported

• CAS Number :

  [2390-54-7]