BIP-135

• Description:

  BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  GSK-3

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR; Stem Cell/Wnt

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/bip-135.html

• Purity:

  99.86

• Solubility:

  DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 70°C)

• Smiles:

  O=C(C(C1=COC2=CC=CC=C12)=C3C4=CN(C)C5=C4C=C(Br)C=C5)NC3=O

• Molecular Formula:

  C21H13BrN2O3

• Molecular Weight:

  421.24

• Precautions:

  H301

• References & Citations:

  [1]Chen PC, et al. Identification of a Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitor, BIP-135, that Prolongs the Median Survival Time of Δ7 SMA KO Mouse Model of Spinal Muscular Atrophy. ACS Chem Neurosci. 2012 Jan 18;3 (1) :5-11.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  GSK-3α; GSK-3β

• CAS Number:

  [941575-71-9]