BMI-135

• UNSPSC Description:

  BMI-135 is a selective estrogen mimic, that exhibits agonist activity for estrogen receptor. BMI-135 induces rapid endoplasmic reticulum stress response (UPR) and apoptosis in breast cancer cells[1].

• Target Antigen:

  Apoptosis; Estrogen Receptor/ERR

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Vitamin D Related/Nuclear Receptor

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bmi-135.html

• Smiles:

  O=C(C1=CC=C(C#C)C=C1)C2=C(C3=CC=C(F)C=C3)C4=C(S2)C=C(O)C=C4

• Molecular Weight:

  372.41

• References & Citations:

  [1]Abderrahman B, et al., Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer. Mol Cancer Ther. 2021 Jan;20(1):11-25.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1608099-90-6