BMI-135

• Description :

  BMI-135 is a selective estrogen mimic, that exhibits agonist activity for estrogen receptor. BMI-135 induces rapid endoplasmic reticulum stress response (UPR) and apoptosis in breast cancer cells[1].

• CAS Number :

  [1608099-90-6]

• UNSPSC :

  12352100

• Target :

  Apoptosis; Estrogen Receptor/ERR

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Vitamin D Related/Nuclear Receptor

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/bmi-135.html

• Smiles :

  O=C(C1=CC=C(C#C)C=C1)C2=C(C3=CC=C(F)C=C3)C4=C(S2)C=C(O)C=C4

• Molecular Formula :

  C23H13FO2S

• Molecular Weight :

  372.41

• References & Citations :

  [1]Abderrahman B, et al., Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer. Mol Cancer Ther. 2021 Jan;20 (1) :11-25.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported