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VY-3-135

CAT: 0804-HY-145953-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-145953-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VY-3-135 is a potent, orally active, and stable ACSS2 inhibitor with an IC50 value of 44 nM. VY-3-135 is specific to ACSS2 among the AcCoA synthetase family of enzymes. VY-3-135 does not inhibit ACSS1 or ACSS3 enzymatic activity. VY-3-135 can be used for the research of breast cancer[1].
CAS Number
1824637-41-3
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Acetyl-CoA Carboxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vy-3-135.html
Purity
99.94
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CCN(C(C(C1=CC=CC=C1)(C2=CC=CC=C2)O)=N3)C4=C3C=CC(C(NC[C@@H](C)O)=O)=C4
Molecular Formula
C26H27N3O3
Molecular Weight
429.51
Precautions
H315, H319
References & Citations
[1]Katelyn D Miller, et al. Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth. Cancer Res. 2021 Mar 1;81 (5) :1252-1264.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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