WY-135

• Description:

  WY-135 is an ALK (IC50=1.4 nM) and ROS1 (IC50=1.1 nM) dual inhibitor.

• UNSPSC:

  12352005

• Target:

  Anaplastic lymphoma kinase (ALK) ; ROS Kinase

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/WY-135.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC (C) S (C1=C (NC2=NC (NC3=C (OC) C=C (N4C=C (CN5CCN (C) CC5) N=N4) C=C3) =NC=C2Cl) C=CC=C1) (=O) =O

• Molecular Formula:

  C28H34ClN9O3S

• Molecular Weight:

  612.15

• References & Citations:

  [1]Wang Y, et al. Discovery of novel 2,4-diarylaminopyrimidine analogues as ALK and ROS1 dual inhibitors to overcome crizotinib-resistant mutants including G1202R. Eur J Med Chem. 2018 Jan 1;143:123-136.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2163060-83-9