YM-08

• UNSPSC Description:

  YM-08 (Compounds 7a) is a brain-penetrant inhibitors of SIRT2,with the IC50 of 19.9 μM. YM-08 also is inhibitor of Hsp70[1].

• Target Antigen:

  HSP; Sirtuin

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease

• Field of Research:

  Cancer; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ym-08.html

• Smiles:

  O=C1N(CC)/C(S/C1=C2SC3=CC=CC=C3N/2C)=C\C4=NC=CC=C4

• Molecular Weight:

  367.49

• References & Citations:

  [1]Abbotto E, et al. Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays. Pharmaceuticals (Basel). 2023;16(9):1316. Published 2023 Sep 18.

• Shipping Conditions:

  Room temperature

• CAS Number:

  812647-88-4