YM-750

CAT: 0804-HY-107396-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-107396-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YM-750 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50=0.18 μM) . ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A[1][2].
CAS Number
[138046-43-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Acyltransferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ym-750.html
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=C(C)C=C(C)C=C1C)N(C2CCCCCC2)CC3=CC(CC4=C5C=CC=C4)=C5C=C3
Molecular Formula
C31H36N2O
Molecular Weight
452.63
Precautions
H302, H315, H319, H335
References & Citations
[1]Nagata Y, et al. N-[2-[N'-pentyl- (6,6-dimethyl-2,4-heptadiynyl) amino]ethyl]- (2-methyl-1-naphthylthio) acetamide (FY-087) . A new acyl coenzyme a:cholesterol acyltransferase (ACAT) inhibitor of diet-induced atherosclerosis formation in mice. Biochem Pharmacol. 1995;49 (5) :643-651.|[2]Chang C, et al. Human acyl-CoA:cholesterol acyltransferase (ACAT) and its potential as a target for pharmaceutical intervention against atherosclerosis. Acta Biochim Biophys Sin (Shanghai) . 2006;38 (3) :151-156.|[3]Miike T, et al. Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell-derived foam cells. Life Sci. 2008;82 (1-2) :79-84.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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Alternative Products

CatalogName
MBS3616327-01YM-750
sc-358844AYM 750
A11395-5YM 750 5mg
A11395-50YM 750 50mg
A11395-200YM 750 200mg
A11395-10YM 750 10mg
A11395-25YM 750 25mg
A11395-100YM 750 100mg
A11395-2YM 750 2mg
A11395-10mM-DYM 750 10mM * 1mL in DMSO

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