YM-58790

• Description:

  YM-58790 is a potent antagonist of mAChR. YM-58790 binds M1, M2, M3 with Ki values of 28 nM, 260 nM, and 15 nM. YM-58790 exhibits potent inhibitory activity on bladder pressuer in reflexly-evoked rhythmic contraction in rats[1].

• UNSPSC:

  12352005

• Target:

  MAChR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/YM-58790.html

• Purity:

  98.21

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (OC1CCN (CC2=CC=C (NC) C=C2) CC1) NC (C3=CC=CC=C3) C4=CC=CC=C4.[H]Cl

• Molecular Formula:

  C27H32ClN3O2

• Molecular Weight:

  466.01

• References & Citations:

  [1]Naito R, et al. Selective muscarinic antagonists. I. Synthesis and antimuscarinic properties of 4-piperidyl benzhydrylcarbamate derivatives. Chem Pharm Bull (Tokyo) . 1998 Aug;46 (8) :1274-85.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• Isoform:

  MAChR1; mAChR2; mAChR3

• CAS Number:

  214558-72-2