YM-08

• Background:

  YM-08 is a Heat Shock Protein 70 (Hsp70) inhibitor that is blood-brain barrier permeable. YM-08 is a neutral derivative of the Hsp70 inhibitor MKT-077. MKT-077 reduces tau levels in cellular models, but it doesn′t penetrate the blood brain barrier. Although YM-08 was somewhat less effective than MKT-077 in anti-tau and anticancer assays, it selectively reduced pathogenic tau in brain slices, which MKT-077 did not. Furthermore,YM-08 was not retained in the kidney leading one to speculate that it would not have the nephrotoxicity that was a problem for MKT-077 in clinical trials. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.

• Description:

  Hsp70 Inhibitor

• Product Name Alternative:

  (2Z,5E) -3-ethyl-5- (3-methyl-1,3-benzothiazol-2-ylidene) -2- (pyridin-2-ylmethylidene) -1,3-thiazolidin-4-one, YM8, YM08

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Heat Shock | Apoptosis | Cell Signaling | Neuroscience | Neurodegeneration | Alzheimer's Disease

• Purity:

  >99% (HPLC)

• Weight:

  0.025

• Format:

  Yellow-orange solid

• Solubility:

  Soluble in DMSO

• Molecular Formula:

  C19H17N3OS2

• Molecular Weight:

  367.49

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Miyata, Y. et al. 2013 ACS Chemical Neuroscience Jun 19;4(6):930-9. doi: 10.1021/cn300210g

• CAS Number:

  812647-88-4